Triethylamine → 1-(2-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one

HRID 507532

反応式

HRID 507532 の反応式
[S:1]1[C:5]([C:6]2[CH:11]=[CH:10][N:9]=[C:8](S(C)(=O)=O)[N:7]=2)=[CH:4][C:3]2[CH:16]=[CH:17][CH:18]=[CH:19][C:2]1=2.[NH2:20][CH2:21][CH2:22][N:23]1[CH2:27][CH2:26][NH:25][C:24]1=[O:28].C(N(CC)CC)C>COC(O)C>[S:1]1[C:5]([C:6]2[CH:11]=[CH:10][N:9]=[C:8]([NH:20][CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][NH:25][C:24]3=[O:28])[N:7]=2)=[CH:4][C:3]2[CH:16]=[CH:17][CH:18]=[CH:19][C:2]1=2

参加物

5

反応物 3

HCID 8471TriethylamineHCID 80480N-(2-Aminoethyl)ethyleneureaHCID 574288274-(Benzo[b]thiophen-2-yl)-2-(methylsulfonyl)pyrimidine

生成物 1

HCID 602043061-(2-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one

試薬・触媒・溶媒 1

HCID 30156371-Methoxyethanol溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-(benzo[b]thiophen-2-yl)-2-(methylsulfonyl)pyrimidine (75 mg, 0.26 mmol)), 1-(2-aminoethyl)imidazolidin-2-one (33 mg, 0.26 mmol) and triethylamine (32 mg, 0.31 mmol) in methoxyethanol (3 mL) was heated at 100° C. overnight. After cooling to rt the solvent was removed in vacuo and the product was purified by chromatography eluting with methanol/dichloromethane (1:20) to give the title compound as a slightly yellow solid (56 mg, 64%). MS (M+H)+ 340.

後処理

  1. temperatureAfter cooling to rt the solvent
  2. customwas removed in vacuo
  3. customthe product was purified by chromatography
  4. washeluting with methanol/dichloromethane (1:20)

出典と根拠

ORDレコード
ord-72932030c4064bb58a23803b89e4bfa8
出典データセット
uspto-grants-2010_08
特許番号
US07786132B2

関連ノート

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