2-Chloro-1,1-dimethoxyethane → 2-(N-Methyl-N-phenylamino)thiazole

HRID 507606

反応式

HRID 507606 の反応式
[CH3:1][N:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([NH2:5])=[S:4].CO[CH:14](OC)[CH2:15]Cl>C1(C)C=CC=CC=1>[CH3:1][N:2]([C:3]1[S:4][CH:14]=[CH:15][N:5]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 609862-Chloro-1,1-dimethoxyethaneHCID 7236311-Methyl-1-phenylthiourea

生成物 1

HCID 234593752-(N-Methyl-N-phenylamino)thiazole

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 10 g (60 mmol) of N-methyl-N-phenylthiourea in 100 mL of toluene was treated with 7.2 mL (63 mmol) of chloroacetaldehyde dimethylacetal and heated at reflux for 12 h. The solvent was removed in vacuo and the residue purified by flash chromatography eluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane to deliver the title compound. MS (M+H)+ 191.

後処理

  1. temperatureheated
  2. temperatureat reflux for 12 h
  3. customThe solvent was removed in vacuo
  4. customthe residue purified by flash chromatography
  5. washeluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane

出典と根拠

ORDレコード
ord-02e610bd787749ae9e8cb99fa034b663
出典データセット
uspto-grants-2010_08
特許番号
US07786132B2

関連ノート

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