Dimethylformamide dimethyl acetal → 2-(2-Bromothiophene-5-carbonyl)-3-(dimethylamino)acrylonitrile

HRID 507658ノート

反応式

HRID 507658 の反応式
[Br:1][C:2]1[S:6][C:5]([C:7](=[O:11])[CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Br:1][C:2]1[S:6][C:5]([C:7]([C:8](=[CH:14][N:15]([CH3:17])[CH3:16])[C:9]#[N:10])=[O:11])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 112876633-(5-Bromothiophen-2-yl)-3-oxopropanenitrile

生成物 1

HCID 543239012-(2-Bromothiophene-5-carbonyl)-3-(dimethylamino)acrylonitrile

反応条件

温度
100 °C

実験手順

3-(5-Bromothiophen-2-yl)-3-oxopropanenitrile (4g, 17 mmol) was treated with dimethyl formamide dimethylacetal and the mixture heated to 100° C. After 1 h, the mixture was allowed to cool down to room temperature. The yellow solid that precipitated was collected by suction filtration and washed well with diethyl ether. Yield=4.6 g. MS (M+H)+ 284.

後処理

  1. temperatureto cool down to room temperature
  2. filtrationThe yellow solid that precipitated was collected by suction filtration
  3. washwashed well with diethyl ether

出典と根拠

ORDレコード
ord-9df3087e96cb438f80605948dc34ab13
出典データセット
uspto-grants-2010_08
特許番号
US07786132B2

反応ノート

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