Water → (2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

HRID 507786

反応式

HRID 507786 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH3:10])[CH:9]=1)[CH:5]=O.C1C=CC([CH:17]([NH2:20])CO)=CC=1.[OH2:21].[C:22]1([CH3:28])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:27]1([C@@H:22]([CH:28]=[CH:5][C:4]2[CH:3]=[C:2]([CH3:1])[CH:9]=[C:8]([CH3:10])[CH:7]=2)[CH2:23][OH:21])[CH:26]=[CH:25][CH:24]=[N:20][CH:17]=1

参加物

5

反応物 4

HCID 962WaterHCID 1140TolueneHCID 34225Benzaldehyde, 3,5-dimethyl-HCID 924662-Amino-2-phenylethanol

生成物 1

HCID 68464252(2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

実験手順

A solution of 3,5-dimethylbenzaldehyde (30.0 g) and (R)-phenylglycinol (30.7 g) in toluene (200 ml) was refluxed for 3 hours with removing water. The reaction solution was concentrated to give the title compound (59.7 g) having the following physical data.

後処理

  1. concentrationThe reaction solution was concentrated

出典と根拠

ORDレコード
ord-4f181c044fb94d2fad5acf4989f8d97a
出典データセット
uspto-grants-2010_08
特許番号
US07786161B2

関連ノート

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