N,N-dimethyl-m-phenylenediamine → 4-N-[3-(dimethylamino)phenyl]pyrido[4,3-d]pyrimidine-4,7-diamine

HRID 50788

反応式

HRID 50788 の反応式
[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](SC)=[N:7][CH:6]=[N:5][C:4]=2[CH:3]=1.[CH3:14][N:15]([CH3:23])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1>>[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8]([NH:22][C:18]3[CH:19]=[CH:20][CH:21]=[C:16]([N:15]([CH3:23])[CH3:14])[CH:17]=3)=[N:7][CH:6]=[N:5][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 76084N,N-dimethyl-m-phenylenediamineHCID 104425627-Amino-4-methylthiopyrido[4,3-d]pyrimidine

生成物 1

HCID 53280674-N-[3-(dimethylamino)phenyl]pyrido[4,3-d]pyrimidine-4,7-diamine収率 32%

反応条件

温度
190 °C

実験手順

A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (245 mg, 1.28 mmol) (described in a previous experimental) and N,N-dimethyl-1,3-phenylenediamine (1.60 g, 11.8 mmol) is stirred under N2 at 190° C. for 1 h, and the resulting product is chromatographed (twice) over alumina (3% EtOH/CHCl3) to give 7-amino-4-(3-dimethylaminoanilino)pyrido[4,3-d]pyrimidine (113 mg, 32%) as a pale yellow solid. 1H NMR (DMSO) δ 9.66 (1H, brs), 9.33 (1H, s), 8.36 (1H, s), 7.22 (1H, brd, J=7.8 Hz), 7.16 (2H, m), 6.57 (2H, brs), 6.51 (1H, ddd, J=8.0, 2.3, 1.2 Hz), 6.42 (1H, s), 2.91 (5H, s)

後処理

  1. customthe resulting product is chromatographed (twice) over alumina (3% EtOH/CHCl3)

出典と根拠

ORDレコード
ord-f4312e2c2e854dcaa3bd6df782a6c9f2
出典データセット
uspto-grants-2004_03
特許番号
US06713484B2

関連ノート

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