[C:1]1([C:7]2[N:8]=[C:9]([CH:12]=O)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][OH:22])=[CH:17][CH:16]=1.C(O)(=O)C.ClCCCl>CCCCCC>[C:1]1([C:7]2[N:8]=[C:9](/[CH:12]=[N:14]/[C:15]3[CH:20]=[CH:19][C:18]([CH2:21][OH:22])=[CH:17][CH:16]=3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1A mixture of 4-phenyl-1,3-thiazole-2-carbaldehyde (1.10 g, 5.81 mmol), (4-aminophenyl)methanol (615 mg, 5.0 mmol), acetic acid (0.4 mL) and 1,2-dichloroethane (10 mL) was stirred at room temperature for 30 min. The reaction mixture was diluted with hexane. The precipitated solid was collected by filtration, washed with hexane, and dried to give the title compound (1.30 g, yield 88%) as yellow crystals.
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