Hydrochloric Acid → Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

HRID 508170ノート

反応式

HRID 508170 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:18]([O:20][CH3:21])=[O:19])=[C:11]([CH2:13][O:14]COC)[N:12]=2)=[CH:4][CH:3]=1.Cl>CO.Cl.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]([C:18]([O:20][CH3:21])=[O:19])=[C:11]([CH2:13][OH:14])[N:12]=2)=[CH:6][CH:7]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 58284400Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

生成物 1

HCID 58284345Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid触媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

後処理

  1. extractionextracted three times with in each case 10 ml of diethyl ether
  2. dry with materialThe combined organic phases are dried over magnesium sulfate
  3. customthe solvent is removed on a rotary evaporator
  4. customThe product obtained
  5. customis used without further purification in the subsequent reaction

出典と根拠

ORDレコード
ord-2dadf170b3d6468882b6c489780934f2
出典データセット
uspto-grants-2015_08
特許番号
US09095582B2

反応ノート

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