反応式
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH2:2][SH:3].[Br:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[C:11](F)[CH:10]=1.C(N(CC)CC)C>CS(C)=O>[Br:8][C:9]1[CH:10]=[CH:11][C:12]2[CH:13]=[C:2]([C:1]([O:5][CH2:6][CH3:7])=[O:4])[S:3][C:15]=2[CH:16]=1参加物
5
実験手順
A solution of ethyl thioglycolate (0.65 g, 5.42 mmol), 4-bromo-2-fluorobenzaldehyde (1.0 g, 4.93 mmol) and triethylamine (1.25 mL, 12.3 mmol) in DMSO (5 mL) was heated at 75° C. for 2 h. The mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL), and the combined organic layers were dried over Na2SO4. The drying agent was filtered off, and the solvent was removed in vacuo to give the title compound as an oil (1.29 g, 92%).
後処理
- customThe mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL)
- dry with materialthe combined organic layers were dried over Na2SO4
- filtrationThe drying agent was filtered off
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-366568a30ae74c7994fbf28f9d1095f3
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09095590B2
関連ノート
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