Water → 2-Bromo-4,5-dimethoxybenzoic acid

HRID 508389

反応式

HRID 508389 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=[O:7].[Br:14]Br.O>Cl>[Br:14][C:9]1[CH:10]=[C:11]([O:12][CH3:13])[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[C:6]([OH:8])=[O:7]

参加物

5

反応物 3

HCID 962WaterHCID 7121Veratric AcidHCID 24408Bromine

生成物 1

HCID 2229632-Bromo-4,5-dimethoxybenzoic acid収率 96.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

3,4-Dimethoxybenzoic acid (25.0 g) was suspended in concentrated hydrochloric acid (35%) (500 mL), and bromine (23.0 g, 1.05 equivalents) was added dropwise to the resultant suspension at 25° C. Subsequently, the resultant mixture was stirred for seven hours. Water (500 mL) was added to the mixture, and the mixture was stirred for one hour. Thereafter, the precipitated crystals were filtrated, and then dried under reduced pressure, to thereby produce crude crystals of 2-bromo-4,5-dimethoxybenzoic acid (34.47 g) (yield: 96.2%).

後処理

  1. filtrationThereafter, the precipitated crystals were filtrated
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ab2cb0c75bab4d10a547cd259bedac49
出典データセット
uspto-grants-2015_08
特許番号
US09096511B2

関連ノート

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