Bromine → 3-Bromo-4-methyl-5-nitro-1,2-dihydropyridin-2-one

HRID 508484

反応式

HRID 508484 の反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][NH:5][C:4](=[O:11])[CH:3]=1.[Br:12]Br>O>[Br:12][C:3]1[C:4](=[O:11])[NH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[CH3:1]

参加物

4

反応物 2

HCID 24408BromineHCID 3453714-Methyl-5-nitro-1,2-dihydropyridin-2-one

生成物 1

HCID 401519143-Bromo-4-methyl-5-nitro-1,2-dihydropyridin-2-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
10 °C

実験手順

In a 1000 ml three-necked round-bottomed flask, 5.00 g of 4-methyl-5-nitro-1H-pyridin-2-one (CA registry number: 21901-41-7) is suspended in 500 ml of water. Under stirring, the mixture is kept at a temperature of 40° C. while 1.83 ml of elemental bromine is added dropwise. Stirring at 40° C. is continued for an additional 4 hours. Afterwards, the mixture is cooled to 10° C. and the resulting precipitate collected by filtration and washed with water (4×). After drying, 6.65 g of the title compound is obtained in the form of a beige solid (MP: 237-240° C.).

後処理

  1. additionis added dropwise
  2. stirringStirring at 40° C.
  3. filtrationthe resulting precipitate collected by filtration
  4. washwashed with water (4×)
  5. customAfter drying

出典と根拠

ORDレコード
ord-060f95c1ea164b63ae0bb07e83e11221
出典データセット
uspto-grants-2015_08
特許番号
US09096525B2

関連ノート

読み込み中…