Cinnamoyl Chloride → HCID 22736740、化合物

HRID 50867

反応式

HRID 50867 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH2:14])[CH:2]=1.[C:15](Cl)(=O)/[CH:16]=[CH:17]/[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1(C)C(C)=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:14]=[C:15]2/[CH:16]=[CH:17]/[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:2]=1

参加物

4

反応物 2

HCID 5354261Cinnamoyl ChlorideHCID 22736684N-(3-pyridyl)-o-phenylenediamine

生成物 1

HCID 22736740HCID 22736740、化合物収率 34%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

To a stirred suspension of N-(3-pyridyl)-o-phenylenediamine (0.93 g, 5 mmol; Kirsch, P.; Schoenleben-Janas, A.; Schirmer, R. H. Liebigs Ann. Org. Bioorg. Chem., 1995, 7, 1275) in xylene (60 ml) was added (E)-cinnamoyl chloride (0.83 g, 5 mmol). After stirring at the room temperature for 1h, the resulting mixture was heated to reflux removing water using a Dean-Stark apparatus for 11 h. After cooling, the reaction mixture was concentrated to dryness. The residue was dissolved into ethyl acetate (100 ml), washed consecutively with saturated aqueous sodium bicarbonate solution (50 ml) and brine (50 ml), dried (magnesium sulfate) and concentrated to dryness. The residue was purified by column chromatography (silica gel, 165 g; n-hexane/ethyl acetate (3/2 to 1/1)) to give 0.77 g (34%) of brown solids. Recrystallization from isopropyl ether yielded 0.50 g of the titled compound as pink solids. MW: 297.36; mp: 118.0-118.5° C.; 1H-NMR (CDCl3) δ: 8.84 (1H, dd, J=4.8, 1.5 Hz), 8.79 (1H, d, J=2.6 Hz), 8.00 (1H, d, J=15.8 Hz), 7.88-7.79 (2H, m), 7.61 (1H dd, J=8.1, 4.8 Hz), 7.50-7.44 (2H, m), 7.39-7.15 (6H, m), 6.78 (1H, d, J=15.8 Hz).

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureto reflux
  3. customremoving water using a Dean-Stark apparatus for 11 h
  4. temperatureAfter cooling
  5. concentrationthe reaction mixture was concentrated to dryness
  6. dissolutionThe residue was dissolved into ethyl acetate (100 ml)
  7. washwashed consecutively with saturated aqueous sodium bicarbonate solution (50 ml) and brine (50 ml)
  8. dry with materialdried (magnesium sulfate)
  9. concentrationconcentrated to dryness
  10. customThe residue was purified by column chromatography (silica gel, 165 g; n-hexane/ethyl acetate (3/2 to 1/1))

出典と根拠

ORDレコード
ord-3de14cb4fccf41cc953a450d772b35b6
出典データセット
uspto-grants-2004_03
特許番号
US06713482B2

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