Methylhydrazine → N-methyl-2-morpholinoacetohydrazide

HRID 508686ノート

反応式

HRID 508686 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]C)=O)[CH2:3][CH2:2]1.[CH3:12][NH:13][NH2:14]>C(O)C>[CH3:12][N:13]([C:8](=[O:10])[CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)[NH2:14]

参加物

4

反応物 2

HCID 6061MethylhydrazineHCID 1268178Methyl Morpholinoacetate

生成物 1

HCID 86703007N-methyl-2-morpholinoacetohydrazide収率 49.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
95 °C

実験手順

In a 25 mL, sealed tube, methyl 2-morpholinoacetate (0.5 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Methylhydrazine (0.16 g, 1.1 eq.) was introduced dropwise at RT and the reaction mixture was refluxed at 95° C. for 48 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude N-methyl-2-morpholinoacetohydrazide (0.27 g) which was used without further purification in the following step.

後処理

  1. customIn a 25 mL, sealed tube
  2. concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)

出典と根拠

ORDレコード
ord-b3474f529fd14022bccf6ff838c738a6
出典データセット
uspto-grants-2015_08
特許番号
US09096543B2

反応ノート

読み込み中…