Sulfuric Acid → 2-Chloro-6-fluorobenzamide

HRID 508725

反応式

HRID 508725 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:12]>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]([NH2:5])=[O:12]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 695872-Chloro-6-fluorobenzonitrile

生成物 1

HCID 985642-Chloro-6-fluorobenzamide

実験手順

A solution of 2-chloro-6-fluorobenzonitrile (8.0 g, 51.61 mmol) in conc. sulphuric acid (50 mL) was heated at 60-70° C. for 6-7 h. The reaction mass was quenched in water and extracted with DCM. The organic layer was dried over anhydrous sodium sulphate and concentrated to afford 5.5 g of desired product.

後処理

  1. customThe reaction mass was quenched in water
  2. extractionextracted with DCM
  3. dry with materialThe organic layer was dried over anhydrous sodium sulphate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-90a5ad7602f44967a9c0810810b17a30
出典データセット
uspto-grants-2015_08
特許番号
US09096545B2

関連ノート

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