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Hydrochloric Acid → (E)-1-(4-Pyrimidyl)-2-styryl-1H-benzimidazole hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| 反応物 | 4-Chloropyrimidine | HCID 642834 | — |
| 反応物 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (E)-1-(4-Pyrimidyl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736756 | — |
反応手順
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 4-Chloropyrimidine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound. MW: 234.81; mp: 191.0-192.0° C.; 1H-NMR (CDCl3) δ: 9.42 (1H, br.s), 9.15 (1H, br.s), 8.26 (1H, d, J=16.5 Hz), 8.08-7.94 (1H, m), 7.82-7.71 (4H, m), 7.58-7.33 (6H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713482B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-a780c9cb4c14491ea5bda352f2a09817 |
| 出典メモ | uspto-grants-2004_03 |