反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:14].[F:15][C:16]([F:29])([F:28])[C:17]1[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=1)/[CH:20]=[CH:21]/[C:22]([Cl:24])=O.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.Cl>CO>[ClH:24].[F:15][C:16]([F:28])([F:29])[C:17]1[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=1)/[CH:20]=[CH:21]/[C:22]1[N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:14]=1参加物
6
実験手順
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and (E)-3-trifluoromethylcinnamoyl chloride (Amino, Y.; Kawada, K.; Toi, K.; Kumashiro, I.; Fukushima, K. Chem. Pharm. Bull., 1988, 36, 4426) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethanol yielded the titled compound. MW: 401.82; mp:>230° C.; 1H-NMR (DMSO) δ: 8.83-8.77 (1H, m), 8.14-8.06 (1H, m), 7.81(1H, d, J=7.7 Hz), 7.67 (1H, dd, J=7.3,4.8 Hz), 7.56-7.22 (10H, m).
後処理
- concentrationConcentration and recrystallization from ethanol
出典と根拠
- ORDレコード
- ord-2d5c40e45c4342a885a813112182c3fc
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713482B2
関連ノート
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