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Hydrochloric Acid → Methyl 2-(benzylamino)acetate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-(Benzylamino)acetic acid | HCID 86965 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Methyl 2-(benzylamino)acetate hydrochloride | HCID 24192994 | 99% |
反応手順
To a N-benzyl glycine 26 (500 mg, 3.0 mmol) in MeOH (6 mL) was added 4M solution of HCl in dioxane (4 mL) and stirred overnight. The reaction mixture was concentrated to afford compound 27 (649 mg, 99%) as a white solid. The crude compound was carried forward without further purification. LRMS (ESI): (calc) 179.2 (found) 180.1 (MH)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09096565B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-38f9f87398bf4542975c2b2409b64c8e |
| 出典メモ | uspto-grants-2015_08 |