2-(4-Bromophenyl)-2-phenyloxirane → 2-(4-Bromophenyl)-2-phenylacetaldehyde

HRID 509192ノート

反応式

HRID 509192 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:10][O:9]2)=[CH:4][CH:3]=1>C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:10]=[O:9])=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 157379652-(4-Bromophenyl)-2-phenyloxirane

生成物 1

HCID 125551782-(4-Bromophenyl)-2-phenylacetaldehyde

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of 2-(4-bromophenyl)-2-phenyloxirane 51 (5.27 g, 19.15 mmol) and BF3OEt2 (3.29 g, 23.20 mmol) in benzene (50 mL) was shaken vigorously in a separatory funnel for 2 minutes then allowed to stand for 3 minutes. The resulting solution was washed twice with aq. sat. NaHCO3 and the organic layer was separated, dried over Na2SO4 and concentrated to afford 2-(4-bromophenyl)-2-phenylacetaldehyde 52. The crude was used in the next step.

後処理

  1. washThe resulting solution was washed twice with aq. sat. NaHCO3
  2. customthe organic layer was separated
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a54fb1f46624462e929cf360baaf291a
出典データセット
uspto-grants-2015_08
特許番号
US09096565B2

反応ノート

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