Dichloromethane → Methyl 4-{[acetyl({1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]methyl}benzoate

関与物質

役割	名称	HCID	仕込み量
反応物	Dichloromethane	HCID 6344	—
反応物	Acetyl chloride	HCID 6367	—
反応物	Triethylamine	HCID 8471	—
反応物	Methyl 4-{[({1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]methyl}benzoate	HCID 59627278	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	Methyl 4-{[acetyl({1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]methyl}benzoate	HCID 59627274	—

反応手順

A solution of methyl 4-{[({1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]methyl}benzoate (133 mg, 400 mmol), DCM (1.33 mL) and Et3N (167 uL, 1.2 mmol) were treated with acetyl chloride (42.7 uL, 0.600 mmol) and stirred for 5 min. The reaction was diluted with EtOAc and washed with 2M aq. HCl, water, brine, dried (MgSO4) and concentrated to afford the requisite compound as a clear, colorless residue. MS: cal'd 375 (MH+), exp 375 (MH+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09096559B2
出典データセット	uspto-grants-2015_08
ORD ID	ord-102039503a4948afaaca594e9e1b5647
出典メモ	uspto-grants-2015_08