Hydrochloric Acid → (S)-(3-Fluoro-4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methanamine Hydrochloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([C@@H:12]([C:20]2[N:25]=[CH:24][CH:23]=[CH:22]N=2)[NH:13][S@](C(C)(C)C)=O)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[ClH:26]>CO>[ClH:26].[F:1][C:2]1[CH:3]=[C:4]([C@@H:12]([C:20]2[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:22][CH:23]=[CH:24][N:25]=2)[NH2:13])[CH:5]=[CH:6][C:7]=1[C:8]([F:9])([F:10])[F:11]参加物
4
実験手順
To a solution of (S)—N—((S)-(3-fluoro-4-(trifluoromethyl)phenyl)-(pyrimidin-2-yl)methyl)-2-methylpropane-2-sulfinamide (100 mg, 0.266 mmol) in MeOH (5 mL) was added hydrogen chloride (0.200 mL, 0.799 mmol) (4.0 M in 1,4-dioxane). The reaction was stirred for 2 h at rt under N2 and then concentrated in vacuo to give the amine as the hydrochloride salt which was used in the next step without further purification.