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HRID 50933作成日：2026年10月25日

2-Fluoropyridine → (E)-5,6-Dimethyl-1-(2-pyridyl)-2-styryl-1H-benzimidazole

https://huagongshe.com/reaction/50933

反応式

関与物質

役割名称HCID仕込み量
反応物2-FluoropyridineHCID 9746—
反応物5,6-dimethyl-2-styryl-1H-benzimidazoleHCID 3767344—
反応物(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazoleHCID 9796241—
生成物(E)-5,6-Dimethyl-1-(2-pyridyl)-2-styryl-1H-benzimidazoleHCID 22736746—

反応手順

The titled compound was prepared from 5,6dimethyl-2-styryl-1H-benzimidazole and 2-fluoropyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). MW: 325.42; mp: 135.8-137.0° C.; 1H-NMR (CDCl3) δ: 8.77 (1H, ddd, J=4.8, 1.8, 0.7 Hz), 7.98 (1H, ddd, J=7.7, 7.7, 1.8 Hz), 7.94 (1H, d, J=16.1 Hz), 7.59 (1H, s) 7.55-7.42 (4H, m), 7.38-7.26 (3H, m), 7.23 (1H, s), 7.12 (1H, d, J=16.1 Hz), 2.39 (3H, s), 2.35 (3H, s).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06713482B2
出典データセットuspto-grants-2004_03
ORD IDord-b7f9ad9fa36b4e1d8d907fde13bd63a9
出典メモuspto-grants-2004_03