6-Chloro-2-nitropyridin-3-amine → 6-Chloropyridine-2,3-diamine
反応式
[Cl:1][C:2]1[N:7]=[C:6]([N+:8]([O-])=O)[C:5]([NH2:11])=[CH:4][CH:3]=1>[Ni].CO>[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([NH2:11])=[CH:4][CH:3]=1参加物
4
実験手順
A mixture of 6-chloro-2-nitropyridin-3-amine (E-23) (8.8 g, 51 mmol, 1.0 eq) and Raney nickel (0.88 g) in Methanol (100 mL) was stirred under hydrogen at RT for 24 h, then filtered and the filtrate was concentrated in vacuo to afford the desired product 6-chloropyridine-2,3-diamine (E-24) (7 g, 95.6% yield) as a pale solid. ESI-MS m/z: 144.05[M+H]+.
後処理
- filtrationfiltered
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-996bbfa716ca4ce1b163b10fbae208df
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09096590B2
反応ノート
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