1,4-Dioxane-2,3-diol → 6-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrido[2,3-b]pyrazine

HRID 510101

反応式

HRID 510101 の反応式
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]2[N:19]=[C:18]([NH2:20])[C:17]([NH2:21])=[CH:16][CH:15]=2)=[N:6]1.O[CH:27]1[CH:32](O)OCCO1>C(O)C>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]2[CH:15]=[CH:16][C:17]3[C:18]([N:19]=2)=[N:20][CH:27]=[CH:32][N:21]=3)=[N:6]1

参加物

4

反応物 2

HCID 961701,4-Dioxane-2,3-diolHCID 666140516-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyridine-2,3-diamine

生成物 1

HCID 666142136-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrido[2,3-b]pyrazine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

200 mg (0.598 mmol) of the compound from example 43A were initially charged in ethanol (10 ml), then 144 mg (1.20 mmol) of 2,3-dihydroxy-1,4-dioxane were added and the reaction mixture was stirred at RT for 5 h. The solid formed was filtered off, washed with ethanol and dried under high vacuum. This gave 90 mg (41% of theory) of the title compound in solid form.

後処理

  1. customThe solid formed
  2. filtrationwas filtered off
  3. washwashed with ethanol
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-61161eac05524d42b1f6ab4593423ac4
出典データセット
uspto-grants-2015_08
特許番号
US09096592B2

関連ノート

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