Water → 2-(2,3-dihydro-1H-inden-2-yl)ethanol
反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[CH2:10][C:11](OCC)=[O:12].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>CCOCC.CCOC(C)=O.[O-]S([O-])(=O)=O.[Mg+2]>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1][CH:2]1[CH2:10][CH2:11][OH:12]参加物
7
反応条件
- 温度
- 0 °C
実験手順
To a solution of ethyl 2,3-dihydo-1H-inden-2-ylacetate (285 mg, 1.39 mmol) in Et2O (5 mL) at 0° C. under N2 was added LAH (53 mg, 1.39 mmol). After stirring for 40 minutes at 0° C., 0.4 mL of H2O was added to quench the reaction. The reaction mixture was diluted with EtOAc (100 mL) and MgSO4 was added with stirring. The reaction mixture was then filtered and concentrated in vacuo to a clear oil. 2-(2,3-dihydro-1H-inden-2-yl)ethanol was isolated without further purification.
後処理
- customto quench
- customthe reaction
- additionwas added
- stirringwith stirring
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated in vacuo to a clear oil
出典と根拠
- ORDレコード
- ord-13ceb885699d40588d203440eb85e2b0
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713471B1
反応ノート
読み込み中…