関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Purine | HCID 1044 | — |
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 9-(3-Chloropropyl)purine | HCID 22715671 | 68% |
| 生成物 | HCID 22735881 | HCID 22735881 | 23% |
反応手順
To a solution of purine (360 mg, 3.00 mmol) and 1-bromo-3-chloropropane (1.42 g, 9.0 mmol) in DMF (10 mL) was added K2CO3 (622 mg, 4.5 mmol) at 20° C. The reaction mixture was stirred for 24 h at 20° C. and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed to give 9-(3-chloropropyl)purine (400 mg, 68%) and 7-(3-chloropropyl)purine (136 mg, 23%) as colorless oils.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06713471B1 |
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| 出典データセット | uspto-grants-2004_03 |
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| ORD ID | ord-470d3512ab9e436aa10bae0f745433e9 |
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| 出典メモ | uspto-grants-2004_03 |
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