Hydrochloric Acid → HCID 57471403、化合物

HRID 510539ノート

反応式

HRID 510539 の反応式
[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]#[N:19])[CH:16]=2)[CH2:11][CH2:10][CH:9]1[NH:20]C(=O)OC(C)(C)C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>ClCCl.C(O)(C)C>[NH2:20][CH:9]1[CH:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:17]2[CH:16]=[C:15]([C:18]#[N:19])[CH:14]=[CH:13][C:12]=2[CH2:11][CH2:10]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 57467306HCID 57467306、化合物

生成物 1

HCID 57471403HCID 57471403、化合物

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒HCID 6344Dichloromethane溶媒

実験手順

Tert-butyl 1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1.1 g, 3.03 mmol) was dissolved in dichloromethane (20 mL) and 5 M hydrochloric acid in isopropanol (2 mL) was added. The reaction mixture was stirred at room temperature for 12 h followed by 4 h at 35° C. The solvent was evaporated in vacuo. Water (30 mL) was added and the pH was adjusted to pH 9 using aqueous saturated sodium bicarbonate solution. The aqueous layer was extracted with dichloromethane. The combined extracts were dried (MgSO4) and the solvent was evaporated in vacuo. Yield: 790 mg (3.03 mmol, 100%).

後処理

  1. waitfollowed by 4 h at 35° C
  2. customThe solvent was evaporated in vacuo
  3. additionWater (30 mL) was added
  4. extractionThe aqueous layer was extracted with dichloromethane
  5. dry with materialThe combined extracts were dried (MgSO4)
  6. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-3dff764bf02d4ed59b1cb148154039be
出典データセット
uspto-grants-2015_08
特許番号
US09096619B2

反応ノート

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