化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → (2S)-1-t-Butoxycarbonyl-2-(4-methoxybenzylthiomethyl)pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Methoxy-alpha-toluenethiol | HCID 80407 | — |
| 反応物 | (S)-(-)-N-Boc-prolinol | HCID 643448 | — |
| 反応物 | tert-butyl (2S)-2-[(methanesulfonyloxy)methyl]pyrrolidine-1-carboxylate | HCID 10039261 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (2S)-1-t-Butoxycarbonyl-2-(4-methoxybenzylthiomethyl)pyrrolidine | HCID 54209413 | — |
反応手順
The procedure described in Preparation 5-(2) was repeated, but using 12.16 g of (2S)-1-t-butoxycarbonyl-2-methanesulfonyloxymethylpyrrolidine [prepared by the methanesulfonylation of (2S)-1-t-butoxycarbonyl-2-hydroxymethylpyrrolidine], 7.3 ml of 4-methoxybenzyl mercaptan and 2.3 g of sodium hydride (as a 55% w/w suspension in mineral oil) in 100 ml of dry dimethylformamide, to afford 13.93 g of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242914 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-af1ce96835f14d878c2d09702c43634d |
| 出典メモ | uspto-grants-1993_09 |