化工社化工社 化学情報印刷レポート · 研究参考用
Formaldehyde → (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine | HCID 57043207 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine | HCID 57048351 | 41.7% |
反応手順
The procedure described in Preparation 5-(4) was repeated, but using 2 g of (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine, 35% formalin and 848 mg of sodium cyanoborohydride in the presence of 44 ml of acetonitrile, to afford 883 mg of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242914 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-1fc826cd6595419badb8308649438ba2 |
| 出典メモ | uspto-grants-1993_09 |