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Methyl fluorosulfate → (2S)-1,1-Dimethyl-2-(4-methoxybenzylthiomethyl)pyrrolidinium fluorosulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl fluorosulfate | HCID 9870 | — |
| 反応物 | (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine | HCID 57048351 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2S)-1,1-Dimethyl-2-(4-methoxybenzylthiomethyl)pyrrolidinium fluorosulfonate | HCID 14880299 | — |
反応手順
The procedure described in Preparation 5-(5) was repeated, but using 740 mg of (2S)-2-(4-methoxybenzylthiomethyl)-1-methylpyrrolidine and 243 μl of methyl fluorosulfonate in the presence of 22 ml of methylene chloride, to afford 1.0 g of the title compound as crystals, melting at 150°-153° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242914 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-5a0095e69f164f00815bcbd1c99cbbde |
| 出典メモ | uspto-grants-1993_09 |