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(+-)-3-Quinuclidinol → 3-(4-Methoxybenzylthio)quinuclidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+-)-3-Quinuclidinol | HCID 15381 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Methoxy-alpha-toluenethiol | HCID 80407 | — |
| 反応物 | 1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate | HCID 416494 | — |
| 生成物 | 3-(4-Methoxybenzylthio)quinuclidine | HCID 19797265 | — |
反応手順
The procedure described in Preparation 6-(2) was repeated, but using 3.7 g of 3-methanesulfonyloxyquinuclidine (prepared by the methanesulfonylation of 3-quinuclidinol), 3.0 ml of 4-methoxybenzyl mercaptan and 0.942 g of sodium hydride (as a 55% w/w suspension in mineral oil), to afford 1.74 g of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242914 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-b1ecc63b5cfd4eac90d16e7b577321a5 |
| 出典メモ | uspto-grants-1993_09 |