Dipropan-2-yl(3-nitrophenyl)phosphonate → Dipropan-2-yl(3-aminophenyl)phosphonate

反応式

NC1C=CC(P(=O)(OC(C)C)OC(C)C)=CC=1.[N+:18]([C:21]1[CH:22]=[C:23]([P:27](=[O:36])([O:32][CH:33]([CH3:35])[CH3:34])[O:28][CH:29]([CH3:31])[CH3:30])[CH:24]=[CH:25][CH:26]=1)([O-])=O>>[NH2:18][C:21]1[CH:22]=[C:23]([P:27](=[O:36])([O:28][CH:29]([CH3:31])[CH3:30])[O:32][CH:33]([CH3:35])[CH3:34])[CH:24]=[CH:25][CH:26]=1

参加物

反応物 2

HCID 54035471Dipropan-2-yl(3-nitrophenyl)phosphonate

HCID 86653993Dipropan-2-yl(4-aminophenyl)phosphonate

生成物 1

HCID 13649474Dipropan-2-yl(3-aminophenyl)phosphonate収率 45%

実験手順

Prepared according to the procedure described for dipropan-2-yl (4-aminophenyl)phosphonate using dipropan-2-yl (3-nitrophenyl)phosphonate. Yield: 45%. 1H-NMR (DMSO-d6, 400 MHz): δ=1.15 (d, J=6.4 Hz, 6 H), 1.24 (d, J=6.4 Hz, 6 H), 4.45-4.50 (m, 2 H), 5.35 (s, br, 2 H), 6.70-6.77 (m, 2 H), 6.58 (d, J=8.0 Hz, 1 H), 7.10-7.25 (m, 1 H). MS: m/z 257.97 [MH+].

後処理

customPrepared

出典と根拠

ORDレコード: ord-d061f626274e4c7b9cbd5f42d8aab404
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09096624B2

反応ノート

読み込み中…

参加物