8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-ene → 4-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one

HRID 511427ノート

反応式

HRID 511427 の反応式
[O:1]1[C:5]2([CH2:10][CH2:9][C:8](C3C4C(=CC=CC=4)C(=O)N3C)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.Br[C:23]1[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[C:28]2[C:24]=1[CH2:25][N:26]([CH3:36])[C:27]2=[O:35].O1C2(CCC(B3OC(C)(C)C(C)(C)O3)=CC2)OCC1>>[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:23]3[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[C:28]4[C:24]=3[CH2:25][N:26]([CH3:36])[C:27]4=[O:35])=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

参加物

4

反応物 3

HCID 36970768-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-eneHCID 534078944-Bromo-2-methyl-7-nitroisoindolin-1-oneHCID 866540391,4-dioxaspiro[4,5]dec-7-ene-8-yl-2-methyl-2,3-dihydro-1H-isoindol-1-one

生成物 1

HCID 672551534-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one

実験手順

The title product was prepared according to the procedure for 7-amino-4-(1,4-dioxaspiro[4,5]dec-7-ene-8-yl-2-methyl-2,3-dihydro-1H-isoindol-1-one using 4-bromo-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one and 1,4-dioxaspiro[4,5]dec-7-ene-8-boronic acid pinacol ester.

出典と根拠

ORDレコード
ord-72ed046144b6454f898c7e943b66f07e
出典データセット
uspto-grants-2015_08
特許番号
US09096624B2

反応ノート

読み込み中…