Triphenylphosphine → 4-Bromobenzylamine
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][N:7]=[N+]=[N-])=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CO>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1参加物
4
実験手順
To a stirred solution of azide 55 (0.75 g, 3.54 mmol) in anhydrous methanol (10 mL) was added triphenylphosphine (1.39 g, 5.31 mmol) and the mixture was heated under reflux for 1.5 hours. The reaction mixture was cooled to room temperature and the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel (acetone-hexane) to yield product 56 in 63% yield (0.41 g).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 1.5 hours
- customthe solvent was removed under reduced pressure
- customThe residue was purified by flash column chromatography on silica gel (acetone-hexane)
出典と根拠
- ORDレコード
- ord-64ec4365084a4e599d116e72968b65f5
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102622B2
反応ノート
読み込み中…