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Chloride → 2-(5-Chloropyridin-3-yl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloride | HCID 312 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| 生成物 | 2-(5-Chloropyridin-3-yl)acetonitrile | HCID 55265902 | — |
反応手順
Conversion of the hydroxyl group to the chloride using thionyl chloride, followed by the displacement of the chloride by potassium cyanide was performed using the same procedures described for (6-trifluoromethyl-pyridin-3-yl)-acetonitrile. 1H NMR (400 MHz, CDCl3) δ ppm 8.55 (d, J=2.0 Hz, 1 H), 8.50 (d, J=1.1 Hz, 1 H), 7.73 (s, 1 H), 4.58 (s, 2 H). MS m/z 153.0
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102591B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-7629e815c06247809eb898374acc3379 |
| 出典メモ | uspto-grants-2015_08 |