Ammonia → (2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-yl)methanamine

HRID 512208ノート

反応式

HRID 512208 の反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][O:9]2)=[CH:4][N:3]=1.N>CO.[Ni]>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][O:9]2)=[CH:4][N:3]=1

参加物

5

反応物 2

HCID 222AmmoniaHCID 867162372-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-carbonitrile

生成物 1

HCID 86716238(2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-yl)methanamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒2 回

実験手順

2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-carbonitrile (18 mg, 0.095 mmol) was dissolved in MeOH(5 ml) and 7M NH3 in MeOH (1 ml). Argon was bubbled through the solution. Raney Nickel (6 mg, 0.1 mmol) was added and the flask was fitted with a H2-balloon and stirred at room temperature for 1½ hour. Reaction was filtred through a plug of celite and concentrated in vacuo. Used for next step without further purification. LC-MS (m/z) 194.0 (MH+), tR (minutes, Method D)=0.17.

後処理

  1. customArgon was bubbled through the solution
  2. customthe flask was fitted with a H2-balloon
  3. customReaction
  4. concentrationconcentrated in vacuo
  5. customUsed for next step without further purification

出典と根拠

ORDレコード
ord-6221c7e565f74f5e8f6930fb652ed982
出典データセット
uspto-grants-2015_08
特許番号
US09102591B2

反応ノート

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