2-Chloro-5-methylbenzoic Acid → 2-Chloro-5-methyl-N-[4-(6-methyl-pyridin-3-yl)-tetrahydro-pyran-4-ylmethyl]-benzamide

反応式

[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[N:18]=[CH:17][C:16]([C:19]2([CH2:25][NH2:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:15][CH:14]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([NH:26][CH2:25][C:19]1([C:16]2[CH:17]=[N:18][C:13]([CH3:12])=[CH:14][CH:15]=2)[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1)=[O:6]

参加物

反応物 2

HCID 2404302-Chloro-5-methylbenzoic Acid

HCID 86716258C-[4-(6-methylpyridin-3-yl)-tetrahydropyran-4-yl]methylamine

生成物 1

HCID 867162572-Chloro-5-methyl-N-[4-(6-methyl-pyridin-3-yl)-tetrahydro-pyran-4-ylmethyl]-benzamide

実験手順

From 2-chloro-5-methylbenzoic acid and C-[4-(6-methylpyridin-3-yl)-tetrahydropyran-4-yl]methylamine. LCMS (MH+): m/z=359.0, tR (minutes, Method B)=0.74

出典と根拠

ORDレコード: ord-915f77ae638b47e38a0940c7e9234d0e
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09102591B2

反応ノート

読み込み中…