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Triethylamine → Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 1-Ethyl-1H-pyrrole-3-carboxylic acid | HCID 22737923 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate | HCID 12146426 | — |
反応手順
Into a suspension of 3.33 g (23.9 mmol) of 1-ethyl-3-pyrrolecarboxylic acid, 4.41 g (28.7 mmol) of β-alanine ethyl ester hydrochloride and 5.50 g (28.7 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride in 40 ml of methylene chloride, 4.0 ml (28.7 mmol) of triethylamine were added dropwise under ice cooling and stirring. The reaction mixture was stirred at room temperature for 2.5 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713634B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-bcbd69472e4d41af916ac052054b1c80 |
| 出典メモ | uspto-grants-2004_03 |