Hydrochloric Acid → N-Allyl-5-bromo-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:13]([O:15]C)=O)[C:5](=[O:12])[NH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].Cl>C(N)C=C>[CH2:5]([NH:6][C:13]([C:4]1[C:5](=[O:12])[NH:6][C:7]([C:8]([F:9])([F:10])[F:11])=[C:2]([Br:1])[CH:3]=1)=[O:15])[CH:4]=[CH2:3]参加物
4
実験手順
At room temperature, 250 mg (0.83 mmol) of methyl 5-bromo-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylate were stirred in 5 ml of allylamine for 18 h. By addition of 2N hydrochloric acid, the pH was then adjusted to 2, resulting in the precipitation of a colorless solid. Filtration with suction and drying gave 134 mg (50% of theory) of the product.
後処理
- customresulting in the precipitation of a colorless solid
- filtrationFiltration with suction
- customdrying
- customgave 134 mg (50% of theory) of the product
出典と根拠
- ORDレコード
- ord-622775384f8845cdb44408107cea9955
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102623B2
反応ノート
読み込み中…