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(2-(Difluoromethyl)phenyl)boronic acid → 1-[1-(4-Cyano-phenyl)-ethyl]-5-(3-difluoromethyl-phenyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-(Difluoromethyl)phenyl)boronic acid | HCID 44717243 | — |
| 反応物 | 1-(4-Cyano-benzyl)-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711527 | — |
| 反応物 | 5-Bromo-1-(4-cyano-benzyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711528 | — |
| 反応物 | 5-Bromo-1-[1-(4-cyano-phenyl)-ethyl]-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711530 | — |
| 生成物 | 1-[1-(4-Cyano-phenyl)-ethyl]-5-(3-difluoromethyl-phenyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711529 | — |
反応手順
Preparation 3 is prepared following the procedure described for preparation 1d, substituting 3-(trifluoromethyl)phenylboronic acid with 2-(difluoromethyl)phenylboronic acid and substituting preparation 1c with preparation 2b as starting material. ESI mass spectrum: [M+H]+=409; Retention time HPLC: 1.00 min (Z018_S04).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102624B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-ee70be4464134afeb5a8e4b8bf19bd9c |
| 出典メモ | uspto-grants-2015_08 |