Bromine → 5-Bromo-1-[1-(4-cyano-phenyl)-ethyl]-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide

HRID 512496

反応式

HRID 512496 の反応式
[CH3:1][S:2]([C:5]1[CH:32]=[CH:31][C:8]([CH2:9][NH:10][C:11]([C:13]2[C:18](=[O:19])[C:17]([Br:20])=[C:16]([CH3:21])[N:15]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=3)[CH:14]=2)=[O:12])=[CH:7][CH:6]=1)(=[O:4])=[O:3].Cl.[CH3:34]S(C1C=CC(CN)=CC=1)(=O)=O.BrBr>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:9][NH:10][C:11]([C:13]2[C:18](=[O:19])[C:17]([Br:20])=[C:16]([CH3:21])[N:15]([CH:22]([C:23]3[CH:24]=[CH:25][C:26]([C:29]#[N:30])=[CH:27][CH:28]=3)[CH3:34])[CH:14]=2)=[O:12])=[CH:31][CH:32]=1)(=[O:3])=[O:4]

参加物

4

反応物 3

HCID 24408BromineHCID 27292694-Methylsulfonylbenzylamine hydrochlorideHCID 867115365-Bromo-1-(4-cyano-benzyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide

生成物 1

HCID 867115385-Bromo-1-[1-(4-cyano-phenyl)-ethyl]-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide

実験手順

5-Bromo-1-(4-cyano-benzyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide can be prepared as described for preparation 9, substituting methylamine with 4-methylsulfonylbenzylamine hydrochloride; ESI mass spectrum: [M+H]+=528 (bromine isotope pattern); Retention time HPLC: 0.95 min (Z018_S04).

後処理

  1. customas described for preparation 9
  2. custom0.95 min (Z018_S04)

出典と根拠

ORDレコード
ord-81ee101f7a2a4cc791845e4b87fab65a
出典データセット
uspto-grants-2015_08
特許番号
US09102624B2

関連ノート

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