1-Naphthyl Isothiocyanate → 5-Amino-2-(naphthalen-1-ylamino)thiazole-4-carboxamide

HRID 512524

反応式

HRID 512524 の反応式
[NH2:1][CH:2]([C:6]#[N:7])[C:3]([NH2:5])=[O:4].[N:8]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1)=[C:9]=[S:10]>CCOC(C)=O>[NH2:7][C:6]1[S:10][C:9]([NH:8][C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)=[N:1][C:2]=1[C:3]([NH2:5])=[O:4]

参加物

4

反応物 2

HCID 110801-Naphthyl IsothiocyanateHCID 983412-Amino-2-cyanoacetamide

生成物 1

HCID 867033685-Amino-2-(naphthalen-1-ylamino)thiazole-4-carboxamide収率 48.7%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a suspension of 2-amino-2-cyanoacetamide (0.25 g, 2.53 mmol) in EtOAc (8 mL), was added 1-isothiocyanatonaphthalene (0.467 g, 2.53 mmol), and the mixture was refluxed for 30 min. The solvent was evaporated under reduced pressure, and the resulting crude residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.35 g (48% yield) of the titled compound.

後処理

  1. temperaturethe mixture was refluxed for 30 min
  2. customThe solvent was evaporated under reduced pressure
  3. customthe resulting crude residue was purified by silica gel column chromatography
  4. washeluted with 2% MeOH in DCM

出典と根拠

ORDレコード
ord-f4cf05c10fd2464ba09c7430bbfd55e5
出典データセット
uspto-grants-2015_08
特許番号
US09102637B2

関連ノート

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