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5-(4-Methyl-3-nitrobenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide → 5-(3-Amino-4-methylbenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(4-Methyl-3-nitrobenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide | HCID 86703371 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 生成物 | 5-(3-Amino-4-methylbenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide | HCID 72550409 | 51.1% |
反応手順
To a mixture of 5-(4-methyl-3-nitrobenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide (0.07 g, 0.15 mmol) in MeOH-THF (10 mL, 1:1) was added 10% Pd/C (0.014 g) under N2-atmosphere. The mixture was stirred for 16 hrs under hydrogen atmosphere. The insoluble material was then filtered off, and the filtrate was concentrated under reduced pressure to give 0.032 g (49% yield) of the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102637B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-259df8815fd241989c8d8e9d21a62a95 |
| 出典メモ | uspto-grants-2015_08 |