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2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-2-cyanoacetamide | HCID 98341 | — |
| 反応物 | 6-Isothiocyanatoquinoline | HCID 13718422 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide | HCID 86703376 | 65.4% |
反応手順
A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102637B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-c7a2e6ea4fa742208557da471a08eaa9 |
| 出典メモ | uspto-grants-2015_08 |