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HRID 512541作成日：2026年10月27日
1-Methylpiperazine → 5-[4-(4-Methylpiperazin-1-yl)benzamido]-2-(quinolin-6-ylamino)thiazole-4-carboxamide
https://huagongshe.com/reaction/512541
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 5-(4-Fluorobenzamido)-2-(quinolin-6-ylamino)thiazole-4-carboxamide | HCID 86703377 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 5-[4-(4-Methylpiperazin-1-yl)benzamido]-2-(quinolin-6-ylamino)thiazole-4-carboxamide | HCID 72550629 | 45.7% |
反応手順
A mixture of 5-(4-fluorobenzamido)-2-(quinolin-6-ylamino)thiazole-4-carboxamide (90 mg, 0.22 mmol) and 1-methyl-piperazine (110 mg, 1.10 mmol) in NMP (3 mL) was heated at 150° C. for 1.5 h. The reaction mixture was diluted with ice-water (5 mL), and the resulting solids were collected by filtration and washed successively with water, ether and dried to give 0.049 g (45% yield) of the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09102637B2 |
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| 出典データセット | uspto-grants-2015_08 |
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| ORD ID | ord-ea320fb378c147d496589bd0072117e7 |
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| 出典メモ | uspto-grants-2015_08 |
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