2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

HRID 512547

反応式

HRID 512547 の反応式
[N:1]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1)=[C:2]=[S:3].[NH2:14][CH:15]([C:19]#[N:20])[C:16]([NH2:18])=[O:17]>CCOC(C)=O>[NH2:20][C:19]1[S:3][C:2]([NH:1][C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]=[CH:6][CH:5]=2)=[N:14][C:15]=1[C:16]([NH2:18])=[O:17]

参加物

4

反応物 2

HCID 983412-Amino-2-cyanoacetamideHCID 114993404-Isothiocyanatoquinoline

生成物 1

HCID 867033825-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.

後処理

  1. temperaturewas refluxed for 90 min
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe resulting solids were collected
  4. washwashed with EtOAc

出典と根拠

ORDレコード
ord-dd0b882fa8f8490fa1dd59d7dfe7fa8d
出典データセット
uspto-grants-2015_08
特許番号
US09102637B2

関連ノート

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