2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide
反応式
[N:1]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1)=[C:2]=[S:3].[NH2:14][CH:15]([C:19]#[N:20])[C:16]([NH2:18])=[O:17]>CCOC(C)=O>[NH2:20][C:19]1[S:3][C:2]([NH:1][C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]=[CH:6][CH:5]=2)=[N:14][C:15]=1[C:16]([NH2:18])=[O:17]参加物
4
実験手順
A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.
後処理
- temperaturewas refluxed for 90 min
- concentrationThe reaction mixture was concentrated in vacuo
- customthe resulting solids were collected
- washwashed with EtOAc
出典と根拠
- ORDレコード
- ord-dd0b882fa8f8490fa1dd59d7dfe7fa8d
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102637B2
反応ノート
読み込み中…