2-Naphthylisothiocyanate → HCID 86703384、化合物

HRID 512550

反応式

HRID 512550 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]=[C:12]=[S:13].[NH2:14][CH:15]([C:21]#[N:22])[C:16]([O:18][CH2:19][CH3:20])=[O:17]>CCO>[NH2:22][C:21]1[S:13][C:12]([NH:11][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[N:14][C:15]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

参加物

4

反応物 2

HCID 742222-NaphthylisothiocyanateHCID 288716Ethyl 2-amino-2-cyanoacetate

生成物 1

HCID 86703384HCID 86703384、化合物収率 67%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of 2-naphthalenyl isothiocyanate (0.5 g, 2.7 mmol) and ethyl 2-amino-2-cyanoacetate (0.38 g, 2.97 mmol) in EtOH (16 mL) was heated at 80° C. for 3 h. The reaction mixture was cooled to rt, and the solvent was concentrated in vacuo. The resulting solids were collected and washed with n-Hexane-EtOAc (1:1) to give 565 mg (67% yield) of the titled compound.

後処理

  1. temperatureThe reaction mixture was cooled to rt
  2. concentrationthe solvent was concentrated in vacuo
  3. customThe resulting solids were collected
  4. washwashed with n-Hexane-EtOAc (1:1)

出典と根拠

ORDレコード
ord-725331d5ea464ea1aa8340dfcfb271b1
出典データセット
uspto-grants-2015_08
特許番号
US09102637B2

関連ノート

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