4-(2,3-Dimethoxybenzoyl)pyridine → (2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol

HRID 51268

反応式

HRID 51268 の反応式
[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:4]=1[C:5]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:6]>CO>[OH:6][CH:5]([CH:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)[C:4]1[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:3]=1[O:2][CH3:1]

参加物

3

反応物 1

HCID 4285494-(2,3-Dimethoxybenzoyl)pyridine

生成物 1

HCID 10890362(2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol収率 92.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 4-(2,3-dimethoxybenzoyl)pyridine (12) (2.10 g, 8.6 mmol) in MeOH (10 mL) is treated with 5% Rh/alumina (0.72 g). The mixture is hydrogenated in a Parr shaker at 55 psig for 22 hours. After filtration through Celite7 filter aid, the filtrate is concentrated at reduced pressure to give the title compound (11) as a solid (2.0 g, 92% yield).

後処理

  1. filtrationAfter filtration through Celite7
  2. filtrationfilter aid
  3. concentrationthe filtrate is concentrated at reduced pressure

出典と根拠

ORDレコード
ord-7e3f5ba32de04fa7ba8b4f049ccb6fe2
出典データセット
uspto-grants-2004_03
特許番号
US06713627B2

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