4-(2,3-Dimethoxybenzoyl)pyridine → (2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol

HRID 51269

反応式

HRID 51269 の反応式
[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:4]=1[C:5]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:6]>CO.[Rh]>[OH:6][CH:5]([CH:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)[C:4]1[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:3]=1[O:2][CH3:1]

参加物

4

反応物 1

HCID 4285494-(2,3-Dimethoxybenzoyl)pyridine

生成物 1

HCID 10890362(2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol

試薬・触媒・溶媒 2

HCID 23948Rhodium触媒HCID 887Methanol溶媒

実験手順

4-(2,3-Dimethoxybenzoyl)pyridine (12) (10.09 g, 42 mmol) was dissolved in 100 mL of methanol and hydrogenated using a 5% rhodium on carbon catalyst. At the conclusion of the reaction, the catalyst was removed by filtration. The filtrate weighed 113.90 g. The reactor and catalyst cake were washed with methanol. The combined washes weighed 165.26 g.

後処理

  1. customAt the conclusion of the reaction
  2. customthe catalyst was removed by filtration
  3. washThe reactor and catalyst cake were washed with methanol

出典と根拠

ORDレコード
ord-6b10edf3e7124686b34939f0cde5bae9
出典データセット
uspto-grants-2004_03
特許番号
US06713627B2

関連ノート

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