関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-Fluorophenylacetyl chloride | HCID 3744988 | 99% |
反応手順
Into a suitable reactor is charged 4-fluorophenylacetic acid (122.5 kg, 795 mol), N,N-dimethylformamide (0.37 kg, 5.1 mol), and toluene (490 kg). Oxalyl chloride (105.2 kg, 829 mol) is added at a rate to maintain the temperature at about 35° C. The solution is stirred for at least 7 hours at about 25° C., typically affording a solution of about 22.1 wt % 4-fluorophenylacetyl chloride (99% yield as determined by HPLC assay).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06713627B2 |
|---|
| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-627f2db91fef4c5b8d7b94a1450d4732 |
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| 出典メモ | uspto-grants-2004_03 |
|---|
