Hydrochloric Acid → 5-Bromopyrazolo[1,5-a]pyridine-3-carboxylic acid

HRID 513019

反応式

HRID 513019 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([C:11]([O:13]CC)=[O:12])=[C:4]2[CH:3]=1.[OH-].[K+].Cl>CCO>[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[C:4]2[CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 53249841Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate

生成物 1

HCID 685073035-Bromopyrazolo[1,5-a]pyridine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspensions of ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate (0.27 g, 1.0 mmol) in EtOH (5 mL) was added 6 N KOH (0.3 uL, 2.0 mmol). The reaction was heated to reflux for 3 hours then cooled to room temperature and neutralized to pH 6 with 1M HCl. The resulting solid was filtered and dried under vacuum to yield 5-bromopyrazolo[1,5-a]pyridine-3-carboxylic acid (I-25) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 8.83 (d, J=7.6 Hz, 1 H), 8.42 (s, 1 H), 8.21 (d, J=2.4 Hz, 1 H), 7.30 (dd, J=2.0, 7.6 Hz, 1 H). MS m/z 240.9, 242.9 (M+1)+.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 3 hours
  3. filtrationThe resulting solid was filtered
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-c655429842094451ae433cdd547fc268
出典データセット
uspto-grants-2015_08
特許番号
US09102671B2

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