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Water → 6-Chloro-4-(thiophen-2-ylmethylamino)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | (2-Thienylmethyl)amine | HCID 34005 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4,6-Dichloronicotinamide | HCID 600044 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 6-Chloro-4-(thiophen-2-ylmethylamino)nicotinamide | HCID 58439831 | 99% |
反応手順
A solution of 4,6-dichloronicotinamide (123 mg, 0.643 mmol), thiophen-2-ylmethanamine (0.065 mL, 0.634 mmol) and DIPEA (0.230 mL, 1.32 mmol) in NMP (4 mL) was stirred at 90 C for 18 h. Water and EtOAc were added. The organic phase was separated, dried over Na2SO4, and concentrated in vacuo to give 6-chloro-4-(thiophen-2-ylmethylamino)nicotinamide as a solid (168 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102625B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-0ad6d4794e8b4922ab2adf64c5bfac28 |
| 出典メモ | uspto-grants-2015_08 |